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KMID : 0614620010380030161
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Korean Journal of Gastroenterology
2001 Volume.38 No. 3 p.161 ~ p.168
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Expression of Cyclooxygenase - 2 and Inducible Nitric Oxide Synthase mRNA in Gastric Cancer
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Park Dong-Il
Rhee Jong-Chul
Sohn Hee Jung
Song Sang-Yong
Kim Young-Ho
Rhee Poong-Lyul
Kim Jae-Jun
Paik Seung-Woon
Choi Kyoo-Wan
Sohn Tae-Sung
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Abstract
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Background/Aims: It has been expected that chronic expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) may play an important role in gastric carcinogenesis. The purpose of our study was to investigate the role of COX-2 and iNOS mRNA expression in gastric carcinogenesis and the correlation between the expression of COX-2 and iNOS mRNA in patients with gastric cancer.
Methods: Twenty-three gastric carcinoma tissue specimens and their adjacent normal mucosa specimens were obtained from surgical resection. The expression of COX-2 and iNOS mRNA were examined by comparative reverse transcriptase-polymerase chain reaction.
Results: COX-2 and iNOS mRNA were expressed significantly higher in gastric cancer tissues than in adj acent normal tissues. There was a significant correlation between the level of COX-2 and iNOS mRNA in carcinoma tissues. There was no significant correlation between the level of COX-2 or iNOS mRNA expression and clinicopathological parameters such as tumor size, depth of invasion, differentiation, Laurens classification, lymph node metastasis, perineural and vascular invasion in these patients.
Conclusions: The expression of COX-2 and iNOS may be one of the factors that contribute to the early stage of gastric carcinogenesis.
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KEYWORD
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Cyclooxygenase-2, Inducible nitric oxide synthase, Gastric cancer
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